Pamidronate

From Ganfyd

(Redirected from Disodium pamidronate)
Jump to: navigation, search

Contents

Introduction

Clinical Use

Indications

Administration

IV

  • up to 90mg in divided doses over 2 to 4 days(hypercalcaemia of malignancy)


Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

  • Nausea
  • Diarrhoea
  • Abdomenal pain and distension
  • Flatulence
  • Dyspepsia
  • In long term use (> 7 years) atypical femoral stem fractures have been associated with alendronate and the potential for decreased bone healing and increasing differential fracture risk is a concern for all bisphosphonates due to their mechanism of action[1]
  • Atrial fibrillation (subject to on going analysis by regulatory agencies).
  • Uveitis (adjusted relative risk = 1.5, 95% CI 1.3 to 1.7) and scleritis (adjusted relative risk = 1.5, 95% CI 1.3 to 1.7)
  • Possibly oesophageal malignancy[2]

Nitrogen-containing bisphosphonates

Nitrogen containing iv bisphosphonates

  • Acute phase reaction with
    • Fever
    • Myalgia
    • Influenzae like symptoms

Special advice

Pharmacology