Dlx genes

From Ganfyd

Jump to: navigation, search

The Dlx genes are a homeobox cluster group. They include:

  • Cluster at Chromosome 2q32
    • DLX1 (distal-less homeobox 1)
      • Some isoforms are involved in craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain
      • May be involved in closure of the ductus arteriosus
    • DLX2 (distal-less homeobox 2)
      • Involved in frontal lobe differentiation
      • Expressed in some advanced adenocarciomas
  • Cluster at Chromosome 17q21
    • DLX3 (distal-less homeobox 3)
      • Mutations cause trichodentoosseous syndrome (TDO) and amelogenesis imperfecta with taurodontism.
    • DLX4 (BP1, DLX7, DLX8, DLX9, distal-less homeobox 4)
      • One isoform functions as a repressor of the beta-globin gene
      • Widely expressed in leukaemia, lung, breast, ovarian and prostate cancers as it upregulates TWIST expression and also induces tumour metastasis.
      • Expressed in the placenta
  • Cluster at Chromosome 7q22
    • DLX5
      • Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation
      • Involved in bone development and fracture healing
    • DLX6
    • DLX6-AS