An unsaturated omega-3 fatty acid. With docosahexaenoic acid (DHA) there is increasing direct evidence that its metabolic products reduce inflammatory mediators by direct action. Higher dietry intake is associated with reduced risk of coronary heart disease events, although unlike docosahexaenoic acid, it does not seem to decrease risk of atrial fibrillation.
- ↑ Groeger AL, Cipollina C, Cole MP, Woodcock SR, Bonacci G, Rudolph TK, Rudolph V, Freeman BA, Schopfer FJ. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Nature chemical biology. 2010 May 2.(Epub ahead of print) (Link to article – subscription may be required.)
- ↑ Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K. Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. The British journal of nutrition. 2010 Feb; 103(4):602-7.(Link to article – subscription may be required.)
- ↑ Virtanen JK, Mursu J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids and risk of hospital diagnosis of atrial fibrillation in men. Circulation. 2009 Dec 8; 120(23):2315-21.(Link to article – subscription may be required.)