Droperidol
From Ganfyd
rINN: Droperidol
Pharmacological Information
Pharmacology Images
Web information on Droperidol
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Droperidol (Less technical, good quality control)
Wikipedia on Droperidol (Less technical, ? quality control)
Contents |
Introduction
Clinical Use
Droperidol is no longer licensed for use in psychiatric disorders
Administration
Dose for age as used in treatment of PONV
- under 55 years IV droperidol 500mcg - 1mg
- over 55 years IV droperidol 250mcg - 500mcg
Class Clinical Issues
Contra-indications
Dementia is probably a contraindication for any antipsychotic (fair evidence for increased mortality in long term use) and has an interesting medicolegal potential as it is unclear if following recent changes in datasheets (SPCs) and warnings from the regulatory authorities (eg FDA) any manufacturer will share liability for out of licence use (off license) use in newly commenced patients. In the UK an urgent review is taking place as of 2008.
- CNS depression
- Phaeochromocytoma
Cautions
- Driving
- Breast feeding and pregnancy (many contra-indicated or best avoided)
- Withdrawal should be gradual
- Hepatic impairment
- Renal impairment
- Cardiovascular disease
- Parkinsonism
- Epilepsy
- Blood dyscrasias
- Depression
- Myasthenia gravis
- Associated with increased venous thromboembolic disease
Side-effects
- Postural hypotension
- Parkinsonism
- Dystonia
- Akathisia
- Tardive dyskinesia
- Jaundice
- Drowsiness
- Apathy
- Excitement
- Neuroleptic malignant syndrome
- Insomia
- Anticholinergic side-effects
- Blood dyscrasias
- Hyperprolactinaemia
- Weight gain
- Skin pigmentation (purple)
- Photosensitisation at higher doses
- Cataracts & corneal opacities
