Duloxetine
From Ganfyd
rINN: Duloxetine
Other Names
Yentreve®,Cymbalta®
Pharmacological Information
Pharmacology Images
Web information on Duloxetine
Mechanism of Action
Serotonin (5-HT) and noradrenaline (NA)inhibitor
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Duloxetine (Less technical, good quality control)
Wikipedia on Duloxetine (Less technical, ? quality control)
Contents |
Introduction
Clinical Use
Indications
- Stress urinary incontinence in woman
- Depression
- Fibromyalgia
Administration
Oral
- 40mg bd Stress urinary incontinence in woman
- 60mg daily Major depression
Clinical Issues
- Sudden withdrawal can precipitate a withdrawal reaction- taper over at least 2 weeks
Contra-indications
Cautions and Interactions
Side effects
- Nausea
- Dry mouth
- Fatigue
- Insomnia
- Constipation
- Otherwise similar to SSRIs
Special advice
Duloxetine has a pain modulating effect similar to amitriptyline and some evidence of effect in chronic pain. This is presumed due to the noradrenergic effect it has which is absent in SSRIs.
