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The gene FGFR1 (FLT2,FLG) at 8p11.23-p11.22 codes for a 822 amino-acid peptide which is processed to fibroblast growth factor receptor 1 a tyosine kinase receptor protein with multiple isoforms. It has a fair importance as defects are associated with:

It is receptor for fibroblast growth factors FGF1, FGF2 and FGF23. As such it is important in tumour cell growth, survival, migration and angiogenesis. Small molecule FGFR inhibitors are in clinical development.

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