Factor X

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Common Name:Factor_X
Biochemical Information
Molecular Structure
Activated Factor X active site structure, with calcium atom in green by itself and a ligand at the protolytic site
FXDomains.png
PubChem on Factor_X
CTD (Comparative Toxicogenomics Database) on Factor_X
Chemical Information on Factor_X
Protein Structural Information on Factor_X
Biological Information (GenomeNet) on Factor_X
Protein Knowledgebase (UniProtKB) on Factor X
Online Mendelian Inheritence in Man (OMIM) on Factor X
Important Issues in Man
  • Molecular Weight: 56,000
  • Normal plasma concentration 10 μg/ml
  • 10-15% of normal concentration required for haemostasis
  • vitamin K dependent blood clotting factor
  • Activated FXa is cofactor of Factor V
Data limitations
Relevant Clinical Literature
Pubmed on Factor X
RCT with Factor X
Systematic reviews of Factor X
Factor X in N Eng J Med, Lancet, JAMA, BMJ
Factor X in Cochrane Collaboration
TRIP Database on Factor X
Google Scholar on Factor X
Bandolier on Factor X
UK Guidance
NHS Evidence on Factor_X
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Factor X
Prodigy Guidance on Factor X
Other Wikis
Medpedia on Factor X (Less technical, good quality control)
Wikipedia on Factor X (Less technical, ? quality control)

Activated to FXa which is cell membrane bound and converts prothrombin to thrombin

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