Factor XI

From Ganfyd

Common Name:Factor_XI

Biochemical Information

Molecular Structure

PubChem on Factor_XI

CTD (Comparative Toxicogenomics Database) on Factor_XI

Chemical Information on Factor_XI

Protein Structural Information on Factor_XI

Biological Information (GenomeNet) on Factor_XI

Protein Knowledgebase (UniProtKB) on Factor XI

Online Mendelian Inheritence in Man (OMIM) on Factor XI

Important Issues in Man

• Molecular Weight: 160,000
• Normal plasma concentration 5 μg/ml
• 20-30% of normal concentration required for haemostasis

Data limitations

Relevant Clinical Literature

Pubmed on Factor XI

RCT with Factor XI

Systematic reviews of Factor XI

Factor XI in N Eng J Med, Lancet, JAMA, BMJ

Factor XI in Cochrane Collaboration

TRIP Database on Factor XI

Google Scholar on Factor XI

Bandolier on Factor XI

UK Guidance

SNOMED search

NHS Evidence on Factor_XI

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Nice Guidance on Factor XI

Prodigy Guidance on Factor XI

Other Wikis

Medpedia on Factor XI (Less technical, good quality control)

Wikipedia on Factor XI (Less technical, ? quality control)

‘’’Factor XI’’’ circulates in plasma as a noncovalent complex with H-kininogen (HK), Once bound to the platelet surface, factor XI is efficiently activated to factor XIa by coagulation proteases such as thrombin and activated factor XII.