Factor XIII

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Common Name:Factor_XIII
Biochemical Information
Molecular Structure
PubChem on Factor_XIII
CTD (Comparative Toxicogenomics Database) on Factor_XIII
Chemical Information on Factor_XIII
Protein Structural Information on Factor_XIII
Biological Information (GenomeNet) on Factor_XIII
Protein Knowledgebase (UniProtKB) on Factor XIII
Online Mendelian Inheritence in Man (OMIM) on Factor XIII
Important Issues in Man
  • Molecular Weight: 320,000
  • Normal plasma concentration 30 μg/ml
  • 1-5% of normal concentration required for haemostasis
Data limitations
Relevant Clinical Literature
Pubmed on Factor XIII
RCT with Factor XIII
Systematic reviews of Factor XIII
Factor XIII in N Eng J Med, Lancet, JAMA, BMJ
Factor XIII in Cochrane Collaboration
TRIP Database on Factor XIII
Google Scholar on Factor XIII
Bandolier on Factor XIII
UK Guidance
NHS Evidence on Factor_XIII
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Factor XIII
Prodigy Guidance on Factor XIII
Other Wikis
Medpedia on Factor XIII (Less technical, good quality control)
Wikipedia on Factor XIII (Less technical, ? quality control)

The last major component of the coagulation and fibrinolysis pathway which stabilises clots. It is a tetramer of two A chains and two B chains found in both plasma but also most cell cyrtoplasm. The A chain, factor XIIIA catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains.

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