Familial atrial fibrillation

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Familial atrial fibrillation (ATFB) is recognised in over 12 varieties due to:
  1. ATFB1 linkage to chromosome 10q22-q24
  2. ATFB2 linkage to chromosome 6q
  3. ATFB3 due to mutations in KCNQ1
  4. ATFB4 due to mutations in KCNE2
  5. ATFB5 linkage to chromosome 4q25
  6. ATFB6 due to mutations in NPPA
  7. ATFB7 due to mutations in KCNA5
  8. ATFB8 linkage to chromosome 16q22
  9. ATFB9 due to mutations in KCNJ2
  10. ATFB10 due to mutations in SCN5A
  11. ATFB11 due to mutations in GJA5
  12. ATFB12 due to mutations in ABCC9

It is also manifest in genetic varieties of short QT syndrome, cardiomyopathy and sick sinus syndrome.