Familial hemiplegic migraine

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Three subtypes, all autosomal dominant with a phenotype of migraine with aura, and ictal hemiparesis are known:

  1. FHM1
    • Missense mutation of CACNA1A gene coding for α1 subunit of a calcium channel membrane protein
    • Some families also have cerebellar degeneration
  2. FHM2
    • Mutation of ATP1A2 gene that codes for α2 subunit of Na/K membrane pump
  3. FHM3