Fatty acid amide hydrolase

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See either:

  1. Fatty-acid amide hydrolase 1 coded by FAAH gene
    • Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis
  2. Fatty-acid amide hydrolase 2 coded by FAAH2 gene
    • Highly expressed in the brain, small intestine and testis

Both degrade the signalling bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby terminating the signalling by these molecules. They both hydrolyze polyunsaturated substrates such as anandamide preferentially as compared to monounsaturated substrates. Inhibitors are under active development as neurones using such signalling appear to central to a number of perceptions and have antidepressant or anxiolytic-like activity.The enteric nervous system's myenteric plexus regulation of gut transit times and other intestinal function also appears to depend upon these enzymes. Genetic variation may be important in some personality traits.

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