Glucagon-like peptide 2

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Glucagon-like peptide-2 (GLP2) is a 33-amino acid derivative of glucagon preproprotein produced by intestinal enteroendocrine cells. Actions include:

  • Stimulates intestinal mucosa proliferation
  • Upregulates villus height
  • Antiapoptotic intestinal cellular responses

It specifically activates the glucagon-like peptide-2 receptor (GLP2R) which is expressed in a number of intestinal cell types. In man it is degraded to GLP2-(3-33) although the mechanism may be different from other mammals. Indeed some of the pathways activated seem unique but include:

Clinical relevance

  • Reduces mortality and mucosal injury in both small and large bowel inflammation
  • Prevents intestinal hypoplasia resulting from total parenteral nutrition
  • Enhances nutrient absorption
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