Glucagon-like peptide 2
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(Redirected from GLP-2)
Common Name:Glucagon-like peptide 2
Alternative Name:GLP2
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on Glucagon-like peptide 2 (Less technical, ? quality control)
Glucagon-like peptide-2 (GLP2) is a 33-amino acid derivative of glucagon preproprotein produced by intestinal enteroendocrine cells. Actions include:
- Stimulates intestinal mucosa proliferation
- Upregulates villus height
- Antiapoptotic intestinal cellular responses
It specifically activates the glucagon-like peptide-2 receptor (GLP2R) which is expressed in a number of intestinal cell types. In man it is degraded to GLP2-(3-33) although the mechanism may be different from other mammals. Indeed some of the pathways activated seem unique but include:
- cyclic AMP protein kinase pathway
- Mitogen-activated protein kinase pathway
- Nitric oxide-dependent enteric neural GLP-2R affects intestinal blood flow
- Beta-catenin signaling with a necessary cofactor being insulin-like growth factor I to produce crypt cell proliferation.
- Vasoactive intestinal polypeptide modulation of its actions in intestinal inflammation
- Keratinocyte growth factor as a co-factor in colonic mucosal growth
Clinical relevance
- Reduces mortality and mucosal injury in both small and large bowel inflammation
- Prevents intestinal hypoplasia resulting from total parenteral nutrition
- Enhances nutrient absorption