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The GLUD2 gene at Xq24 codes for the 558 amino acid propeptide of glutamate dehydrogenase 2, mitochondrial. This is important in the recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission, although the enzyme is also expressed outside the nervous system, in the testis.

L-glutamate + H2O + NAD(P)+ => 2-oxoglutarate + NH3 + NAD(P)H

The gain of function 1492T-G polymorphism of GLUD2 is associated with earlier onset of Parkinsons disease.