Granulocyte-macrophage colony-stimulating factor

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Common Name:Granulocyte-macrophage colony-stimulating factor
Other Names, such as IUPAC Name
Granulocyte-macrophage colony stimulating factor, granulocyte macrophage colony stimulating factor, colony-stimulating factor, sargramostim, molgramostin, CSF, GM-CSF, CSF-2
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis


A cytokine of the IL-6 family that induces macrophages, granulocytes, eosinophils and erythrocytes coded by the CSF2 gene at 5q31.1. A mutation of this is associated with increased risk of atopic asthma. Deficiency of one of its receptors causes a form of pulmonary alveolar proteinosis.

Pharmacology

rINN: sargramostim
Pharmacological Information
Pharmacology Images
ganulocyte-macrophage colony-stimulating factor, granulocyte-macrophage colony stimulating factor, granulocyte macrophage colony stimulating factor, colony-stimulating factor, sargramostim, molgramostin, CSF, GM-CSF, CSF-2
Web information on sargramostim
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Other Wikis
  • Several forms are marketed for myeloid reconstitution after bone marrow transplantation etc.
  • Sargramostim is not effective in active Crohn's disease[1]

References


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