Gemtuzumab
From Ganfyd
rINN: Gemtuzumab
Other Names
gemtuzumab ozogamicin, Mylotarg®
Pharmacological Information
Pharmacology Images
File:GemtuzumabMolecule.png
Gemtuzumab Molecule
Web information on Gemtuzumab
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Gemtuzumab (Less technical, good quality control)
Wikipedia on Gemtuzumab (Less technical, ? quality control)
Contents |
Introduction
In development targeted at CD33+ive acute myeloid leukaemia.
Clinical Use
Indications
Administration
IV
Clinical Issues
Contra-indications
Cautions and Interactions
Side effects
- Prolonged severe bone marrow suppression
- Hepatoxicity
- Chills, fever and hypotension at time of infusion
Special advice
Pharmacology
When the antibody attaches to CD33, the cells absorb the antibody and its cytotoxic attachment calicheamicin. Calicheamicin on release into the cytosol breaks up the DNA.
