Genetic anticipation

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Genetic anticipation is when in a genetically transmitted disease it is manifest at increasingly younger ages with each succeeding generation, Thus if the offspring of patients develop the disease, they tend to do so at an earlier age than their parents. Certain conditions have this process explained as in Huntington's chorea and SCA-17 where CAG-trinucleotide repeats prevent correct transcription of the relevant gene and accumulate in length through generations.