Geranylgeranyl transferase type-2 subunit alpha

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Common Name:Geranylgeranyl transferase type-2 subunit alpha
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The RABGGTA gene at 14q12 codes for the 567 amino acid peptide geranylgeranyl transferase type-2 subunit alpha. This component peptide of Rab geranylgeranyltransferase is regenerated by transferring its prenylated Rab back to the donor membrane after catalysing the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC or -CCXX. This reaction requires an escort peptide such as Rab proteins geranylgeranyltransferase component A 1.

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