Gluten ataxia

From Ganfyd

Jump to: navigation, search

Gluten ataxia is a form of autoimmune cerebellar ataxia associated with high titres of gliadin antibodies. While well described in coeliac disease it is usually independent of this[1] so is problematically harder to diagnose given move to more specific antibodies in coeliac disease. A homology between the 33-mer gliadin peptide and protein lifeguard 1, a component of the NMDA glutamate receptor ion channel has recently been postulated as an explanation for this and several other associations of coeliac disease[2]