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HAMA is an acronym for Human Anti-Mouse Antibody or Human Anti-Mouse Antibodies

This is an increasing problem as we enter the age of personalised and molecular medicine. A wide rang of biologics have been produced historically from mouse derived sources and there is thus potential for humans to be primed. Where possible there is in therapeutics much to recommend using biologics that do not transfer potental antigen load in this way.

Mouse derived antibodies and antibody fragments are increasingly used in both imaging with radiopharmaceuticals and chemotherapy.

Following initial exposure, a second challenge can cause life threatening anaphylaxis

Some immunology departments can offer testing for this.

The risk effectively contraindicates repeat Fab imaging eg Leucoscan