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Haemostasis is a highly evolved homeostatic mechanism which allows the cessation of blood loss from a damaged blood vessel through coagulation. The coagulation cascade is classically described as acting through intrinsic and extrinsic pathways but this is not sufficiently rigorous with today’s understanding as it fails to account for the negative and positive feedback mechanisms that cross both pathways, that specific coagulation pathways are active at different stages of spatial clot formation (initiation, elongation, and termination) and that the process of fibrinolysis is initiated in parallel.

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