Haptoglobin

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  • A plasma protein produced mainly by the liver.
  • Also an acute phase protein - and so rises in inflammatory conditions.
  • Binds to free haemoglobin in the blood, preventing oxidative damage. The resulting haemoglobin-haptoglobin complex that is scavanged by the reticulo-endothelial system.[1] Haemolysis releases free haemoglobin, which reduces the level of haptoglobin.

References

  1. ↑ Ascenzi P, Bocedi A, Visca P, Altruda F, Tolosano E, Beringhelli T, Fasano M. Hemoglobin and heme scavenging. IUBMB Life. 2005 Nov;57(11):749-59.
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