Hepatosplenomegaly

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Hepatosplenomegaly is the enlargement of the spleen and liver. See also splenomegaly and hepatomegaly. There are many causes:

  1. Chronic liver disease with portal hypertension
  2. Haematological disease:
    1. Lymphoproliferative disorders:
      1. Hodgkins lymphoma
      2. Non-Hodgkins lymphoma
      3. Acute lymphocytic leukaemia
    2. Myeloproliferative disorders:
        1. Acute myleocytic leukaemia
        2. Chronic myleocytic leukaemia
        3. Chronic granulocytic leukaemia
    3. Other :
      1. Pernicious anaemia
      2. Sickle cell disease
      3. Thalassaemia
      4. Haemophagocytic syndrome
  3. Infiltration:
    1. Amyloid
    2. Sarcoid
    3. Gaucher disease
  4. Infection:
    1. Malaria
    2. Schistosomiasis
    3. Viral hepatitis
    4. Epstein-Barr virus
    5. Cytomegalovirus
  5. Connective tissue disease:
    1. SLE
  6. Metabolic:
    1. Acromegaly
    2. Thyrotoxicosis

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