Homeobox protein prophet of Pit-1

From Ganfyd

Jump to: navigation, search
Common Name:Homeobox protein prophet of Pit-1
Other Names, such as IUPAC Name
Pituitary-specific homeodomain factor, PROP-1
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on Homeobox protein prophet of Pit-1 (Less technical, ? quality control)

The PROP1 gene at 5q31.3 codes for the 226 amino acid homeobox protein prophet of Pit-1 which is a pituitary specific transcription factor that plays a crucial role in pituitary organogenesis early in development and so defects cause deficiency of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Mutations cause combined pituitary hormone deficiency 2 (CPHD2, OMIM:262600) with deficiencies of growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, prolactin and adrenocorticotropic hormone.

Personal tools