Homer protein homolog 3
The HOMER3 gene at 19p13.11 codes for a 361 amino acid peptide homer protein homolog 3. There are five isoforms produced by alternative splicing which by analogy are expected to have different properties in the regulation of surface receptors (eg plasticity at glutamatergic synapses) and resultant intracellular calcium release. The gene is expressed in the cerebellum, lung and thymus. It is a negative regulator of T-cell activation like HOMER2. It is important in initiation of neutrophil polarity and motility.
Homer protein homolog 3 interacts with:
- ABI gene family member 3
- Protocadherin Fat 1
- Dynein light chain 2, cytoplasmic
- ELL-associated factor 1
- Proto-oncogene serine/threonine-protein kinase mos
- Paired box protein Pax-6
- An important transcription factor in development of the eye, nose, central nervous system and pancreas.
- Serine/threonine-protein kinase N1
- ↑ Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Molecular biology of the cell. 2015 May; 26(9):1629-1639.(Print-Electronic) (Link to article – subscription may be required.)
- ↑ Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. Journal of neuroinflammation. 2015 Sep; 12:166.(Electronic) (Link to article – subscription may be required.)