Homer protein homolog 3

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The HOMER3 gene at 19p13.11 codes for a 361 amino acid peptide homer protein homolog 3. There are five isoforms produced by alternative splicing which by analogy are expected to have different properties in the regulation of surface receptors (eg plasticity at glutamatergic synapses) and resultant intracellular calcium release. The gene is expressed in the cerebellum, lung and thymus. It is a negative regulator of T-cell activation like HOMER2. It is important in initiation of neutrophil polarity and motility[1].

Antibodies to it are found in some varieties of autoimmune cerebellar ataxia[2]

Homer protein homolog 3 interacts with:

References

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