Islet amyloid polypeptide

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Common Name:Islet amyloid polypeptide
Alternative Name:Amylin, IAPP, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide
Other Names, such as IUPAC Name
Islet amyloid polypeptide (Amylin)
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on Islet amyloid polypeptide (Less technical, ? quality control)

Islet amyloid polypeptide coded for by the IAPP gene is processed from its coded 89 amino acids and cosecreted with insulin (and C-peptide) as a 37 amino acid hormone. It selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle. It delays gastric emptying. The glucagonostatic effect is restricted to meal-related glucagon secretion, and glucagon secretion and glucagon action during hypoglycaemia is preserved. A net weight loss can occur which may be of benefit in obesity as leptin responsiveness is restored[1] by its actions, so analogues such as pramlintide are under development. It is structurally related to calcitonin. The processing of the protein can result in amyloid deposition in the islets as characteristic in type 2 diabetes and insulinomas. The variations in the 8-37 region of human islet amyloid polypeptide explain most of its amyloidogenic properties[2].

References

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