Hyperviscosity syndrome

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A possible complication of myeloma and can be a first presentation of the condition.

Contents

Symptoms

  • Blurred vision
  • Headache
  • Mucosal bleeding
  • Dyspnoea (heart failure)

Signs

  • Retinal vein distension
  • Fundal haemorrhage
  • Papilloedema

Investigations

Management

Plasmapheresis, which should be organised on clinical grounds if symptoms present in those with known myeloma. Isovolaemic venesection is solely a holding measure until plasmapheresis. Definitive chemotherapy for the myleoma (or other rare cause) needs to be instituted.

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