Ibutilide

From Ganfyd

rINN: Ibutilide

Other Names

ibutilide fumarate, Corvert^®

Pharmacological Information

Pharmacology Images

Ibutilide Molecule

Web information on Ibutilide

NHS Evidence on Ibutilide

DrugBank on Ibutilide

Relevant Clinical Literature

Pubmed on Ibutilide

RCT with Ibutilide

Systematic reviews of Ibutilide

Ibutilide in N Eng J Med, Lancet, JAMA, BMJ

Ibutilide in Cochrane Collaboration

TRIP Database on Ibutilide

Google Scholar on Ibutilide

Bandolier on Ibutilide

UK Guidance

SNOMED search

Nice Guidance on Ibutilide

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Ibutilide

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Ibutilide

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Ibutilide (Less technical, good quality control)

Wikipedia on Ibutilide (Less technical, ? quality control)

Introduction

Ibutilide is an antiarrhythmic agent that works by induction of slow inward sodium current, which prolongs the action potential and refractory period of myocardial cells. It is useful where initial electrical cardioversion has failed as in combination has a success rate in AF/A flutter of 100%. Magnesium supplementation makes the drug even more effective and safer.

Clinical Use

Indications

Administration

IV

Clinical Issues

Contra-indications

Cautions and Interactions

Monitor for 4 hours after injection as 4% risk of torsade de pointes and a 45% risk of monomorphic ventricular tachycardia

Side effects

Special advice

Pharmacology