Imipramine was discovered by serendipity to act in depression and thus was the first tricyclic antidepressant. It had been developed as part of a search for drugs useful in the treatment of schizophrenia. It was later demonstrated to be effective in panic attacks.
- Not recommended for former indication of urinary incontinence due to poor relative evidence base
Cautions and Interactions
- ↑ AZIMA H, VISPO RH. Imipramine; a potent new anti-depressant compound. The American journal of psychiatry. 1958 Sep; 115(3):245-6.
- ↑ LEHMANN HE, CAHN CH, DE VERTEUIL RL. The treatment of depressive conditions with imipramine (G 22355). Canadian Psychiatric Association journal. 1958 Oct; 3(4):155-64.
- ↑ Modigh K. Antidepressant drugs in anxiety disorders. Acta psychiatrica Scandinavica. Supplementum. 1987; 335:57-74.