Indinavir

From Ganfyd

rINN: Indinavir

Other Names

Crixivan^®

Pharmacological Information

Pharmacology Images

Indinavir Molecule

Indinavir in the:

BNF-registration required
BNF for children-registration required

DrugBank on Indinavir

PubDrug on Indinavir

UK SPCs of medicines with marketing authorisation

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Mechanism of Action

Inhibits HIV protease

Other Issues for Indinavir

Drinking at least 1.5 litres of fluid a day

Relevant Clinical Literature

Pubmed on Indinavir

NHS Evidence on Indinavir

RCT with Indinavir   from Pubmed

Systematic reviews   from Pubmed

TRIP Database on Indinavir

N Eng J Med, Lancet,JAMA, BMJ   from Pubmed

Cochrane Collaboration   from Pubmed

Google Scholar on Indinavir

Other Literature

PubChem on Indinavir

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Introduction

Clinical Use

Indications

Administration

Oral 800mg tds

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

• Nausea
• Abdominal pain
• Hyperbilirubinaemia
• Nephrolithiasis
• Nail changes
• Dry skin

Class Side-Effects

• Lipidystrophy (fat wasting or accumulation - “buffalo hump”)
• Hyperlipidaemia
• Insulin resistance
• Diabetes mellitus
• Gynaecomastia