Indometacin

Upper gastro-intestinal. All NSAIDs are associated with serious gastrointestinal side effects. For non-selective NSAIDs these were most common with azapropazone and least common with Ibuprofen. Selective cyclo-oxygenase-2 inhibitors are associated with a lower risk of gastrointestinal side effects
- Dyspepsia
- Haemorrhage
Renal failure (especially in combination with diuretics and drugs acting on angiotensin system)
Fluid retention

Cardiovascular events. This may be related to degree of cyclo-oxygenase-2 inhibition
Asthma
In chronic heart failure all NSAIDS have a dose-dependent increase in risk of death and increased risk of hospitalization with some such as diclofenac and coxibs having higher hazard ratios^[1]

Some NSAIDs are more likely to cause these side-effects than others but they all appear to be class side-effects

Gastro-intestinal
- Gastritis
- Duodenitis
- Duodenal ulcer
- Gastric ulcer
- Oesophagitis
- Oesophageal ulcer
- Intestinal stricture
- Haemorrhage
- Colitis
- Diarrhoea
- Nausea
Renal
- Failure
- Fluid retention/Oedema
- Papillary necrosis
- Interstitial fibrosis
Hypersensitivity reactions
- Asthma
- Pulmonary eosinophilia
- Rashes
  - Stephen-Johnson syndrome
  - Toxic epidermal necrolysis
  - Photosensitivity
Nervous system
- Headache
- Dizziness
- Vertigo
- Nervousness
- Depression
- Drowsiness
- Insomnia
- Hearing disturbances
- Tinnitus
- Aseptic meningitis
- Aggravate Parkinsonism
Other
- Haematuria
- Hepatic damage
- Alveolitis
- Pancreatitis

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