Indometacin

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Contents

Indication

  • Pain and inflammation in rheumatic disease and other musculoskeletal disorders

Dose

orally
  • Rheumatic disease 50-299mg daily in divided doses
  • Acute gout 150-200mg daily in divided doses
  • Dysmenorrhoea up to 75mg daily
rectally
  • 100mg night and morning if required

Side-effects

Commoner important
Rarer Important
  • Cardiovascular events. This may be related to degree of cyclo-oxygenase-2 inhibition
  • Asthma
  • In chronic heart failure all NSAIDS have a dose-dependent increase in risk of death and increased risk of hospitalization with some such as diclofenac and coxibs having higher hazard ratios[1]
List of NSAID side-effects - many rare

Some NSAIDs are more likely to cause these side-effects than others but they all appear to be class side-effects

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