Influenza A
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Medpedia on Influenza A (Less technical, good quality control)
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A subtype of the influenza virus.
- Can cause influenza pandemics
- Coded proteins are (Numbered according to RNA segment):
- PB-2: cap binding subunit, polymerase, virulence determinant
- PB-1: catalytic subunit of RNA polymerase
- PA subunit of viral RNA polymerase
- Haemagglutinin (HA): receptor binding
- Fifteen subtypes (H1–H15)
- Only H1, H2, and H3 have resulted in stable human to human transmission recently
- Infections with subtypes H7 (duck) and chicken H5 and H9 haemagglutinins have resulted in isolated severe human illness
- NP: Nucleoprotein
- Neuraminidase (NA): helps release of new virus from infected cells
- Nine neuraminidase subtypes (N1–N9)
- Only N1 and N2 have resulted in stable human to human transmission recently
- Nine neuraminidase subtypes (N1–N9)
- Codes for both:
- M1: matrix protein that interacts with genome and the nuclear export factor, assisting in viral assembly
- M2: tetrameric ion channel, that controls pH in Golgi during haemagglutinin synthesis and in virion uncoating
- Non-structural (NS)
- NS1: post-transcription RNA control and an interferon antagonist
- NEP: involved in nuclear export of viral RNA and viral assembly
This article is a work in progress. Please feel free to contribute to it.
