Conserved helix-loop-helix ubiquitous kinase

From Ganfyd

Jump to: navigation, search
Common Name:Conserved helix-loop-helix ubiquitous kinase
Other Names, such as IUPAC Name
Inhibitor of nuclear factor kappa-B kinase subunit alpha, nuclear factor NF-kappa-B inhibitor kinase alpha, transcription factor 16, EC:2.7.11.10, I-kappa-B kinase alpha, IkappaB kinase, I-kappa-B kinase 1, IKK-A, IKK-alpha, IKK-α, IkBKA, IKK1, NFKBIKA, TCF-16
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis

The CHUK gene at 10q24 has 21 exones and encodes a 745 amino acid peptide that is processed to form the alpha subunit of iκß kinase (IKKα, also known as conserved helix-loop-helix ubiquitous kinase). This is activated when phosphorylated. It has an essential role in the proliferation and differentiation of the epidermis. Non functional mutations of CHUK cause the lethal cocoon syndrome[1]. It is also mutated in some skin cancers.

It is a component of IKK which shuttles between the cytoplasm and the nucleus as part of the conventional pathway of NF-kappa-B activation and phosphorylation of inhibitors of NF-kappa-B. This leads to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It also phosphorylates NCOA3 and Ser-10 of histone H3 at NF-kappa-B-regulated promoters found during inflammatory responses triggered by cytokines.

The bacterial toxin YopJ (the outer protein found in Yersinia pestis and Yersinia pseudotuberculosis, coded by the virulence plasmid pCD1) works by acetylation of Thr-179 so blocking the I-kappa-B signaling pathway and causing cell apoptosis[2].

References

Personal tools