Insulin-like growth factor-1
Insulin-like growth factor-I (IGF-I) is a peptide hormone induced peripherally by growth hormone inducing:
- Cell proliferation
- Inhibition of apoptosis.
Its actions can be attenuated before it reaches the IGF-I receptor by IGF-binding proteins and which are regulated in turn by specific proteases.
Measurement of its level in the blood is more reliable to exclude acromegaly than growth hormone. Its levels are highest in late adolescence, increase during pregnancy and decline with age. Low levels occur in:
It is coded for at 12q22-q24.1.