Interferon alphas are a large group of proteins (about 189 amino acids, length varies with post transcription processing) with very similar sequences encoded by several dublicated genes that tend to be expressed more by macrophages than fibroblasts. There are multiple naming conventions. They are type-1 interferons with antiviral activity. There are at least 8 genes that could be active at 9.22p and several apparent pseudogenes. These include:
Interferon stimulates production of oligoadenylate synthetase and phosphorylation/activation of:
- Eukaryotic translation initiation factor 4B (eIF4B)
- Mitogen-activated protein kinase (MAPK)-integrating kinase (Mnk) 1
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- ↑ Kroczynska B, Kaur S, Katsoulidis E, Majchrzak-Kita B, Sassano A, Kozma SC, Fish EN, Platanias LC. Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Molecular and cellular biology. 2009 May; 29(10):2865-75.(Link to article – subscription may be required.)
- ↑ Joshi S, Kaur S, Redig AJ, Goldsborough K, David K, Ueda T, Watanabe-Fukunaga R, Baker DP, Fish EN, Fukunaga R, Platanias LC. Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proceedings of the National Academy of Sciences of the United States of America. 2009 Jul 21; 106(29):12097-102.(Link to article – subscription may be required.)