Interferon gamma

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Immune interferon (IFN-gamma) is encoded on 12q24.1. There is little protein homology with leukocyte interferon alpha (IFN-alpha) or fibroblast interferon beta (IFN-beta) which are called type 1 interferons and have antiviral activity. Rather IFN-gamma is a type-2 interferon) with immunostimulatory actions but little direct antiviral activity. It is produced mainly by activated T-cells and natural killer cells expressing the surface antigens CD4+ and CD8+, but also by B-cells. There is a wide range of receptor proteins. Actions include:

Synthesis induced by:

Inhibited by:

Interferon gamma tests

Interferon-gamma release assays, based on interferon gamma levels, can be used to establish e.g. whether somebody has TB infection.

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