Interleukin-10

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Pubmed on Interleukin-10
RCT with Interleukin-10   from Pubmed
Systematic reviews of Interleukin-10   from Pubmed
Interleukin-10 in N Eng J Med, Lancet,JAMA, BMJ   from Pubmed
Interleukin-10 in Cochrane Collaboration   from Pubmed
TRIP Database on Interleukin-10
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NCBI protein on Interleukin-10
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Produced by: Activated CD8(+) peripheral blood T-cells

  • T-helper CD4(+) T-cell clones after both antigen-specific and polyclonal activation
  • Monocytes following cell activation by bacterial lipopolysaccharides
  • Mast cells

Also produced by B-cell lymphomas

Enhances:

  • B cell survival
  • Cell proliferation
  • Antibody production

Inhibition of monocyte production by:

Downregulates:

  • Expression of Th1 cytokines,
  • MHC class II Antigens
  • Costimulatory molecules on macrophages
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