Interleukin-7 receptor subunit alpha

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Common Name:Interleukin-7 receptor subunit alpha
Other Names, such as IUPAC Name
IL-7R-alpha, CDw127,CD127
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on Interleukin-7 receptor subunit alpha (Less technical, ? quality control)

Interleukin-7 receptor subunit alpha ([[CD127) is a type 1 cytokine receptor coded by the IL7RA gene at 5p13. This is part of the:

There are 3 isoforms:

  1. H20: Membrane bound
  2. H1: Membrane bound
  3. H6: Secreted

Dysfunctional mutations produce severe combined immunodeficiency while mutations in the transmembrane domain has associations with susceptibility to conditions like multiple sclerosis.

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