Interleukin-8
From Ganfyd
Common Name:IL-8
Alternative Name:C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1
Biochemical Information
Molecular Structure
Biological Information (GenomeNet) on IL-8 and some on C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1
Important Issues in Man
Cytokine and protein databases
COPE on Interleukin-8 © copyright conditions here
Relevant Clinical Literature
RCT with IL-8 OR C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1 from Pubmed
Systematic reviews of IL-8 OR C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1 from Pubmed
IL-8 OR C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1 in N Eng J Med, Lancet,JAMA, BMJ from Pubmed
IL-8 OR C-X-C motif chemokine 8, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1,, MDNCF, MONAP, NAP-1 in Cochrane Collaboration from Pubmed
Interleukin-8(IL-8, K60, NAF, GCP1. LECT, LUCT, NAP1, CXCL8, GCP-1, LYNAP, MDNCF, MONAP, NAP-1, SCYB8, TSG-1, AMCF-I, b-ENAP) is a 72 amino acid protein produced from a precursor protein of 99 amino acids coded by the IL8 gene which maps to 4q13.3 . The receptor of this chemokine are high affinity interleukin-8 receptor A and high affinity interleukin-8 receptor B.
- Produced mainly by:
- Activated monocytes
- But also by amongst others:
- Not produced by:
Properties
- Chemotactic for all migratory immune cells.
- Inhibits adhesion of leukocytes to activated endothelial cells.
- Stimulates mitosis in epidermal cells.
- Faciliates angiogenesis
