Interleukin-17

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Actually a very complex unique family of cytokines well conserved in mammals.

  1. IL-17A - Th17 cells
    • Coded for at 6p12
  2. IL-17B (IL-20)
    • Coded for at 5q32-q34
    • Ligand for the cytokine receptor IL17BR
  3. LI-17C (IL-21) - high levels in inflammation
    • Coded for at 16q24
  4. IL-17D - nervous system and skeletal muscle
    • Coded for at 13q12.11
  5. IL-17E (IL-25)
    • Coded for at 14q11.2
    • Two isoforms known
    • Ligand for the cytokine receptor IL17BR
  6. IL-17F (ML-1)- Th17 cells
    • Coded for at 6p12

They have roles in:

Physiology

Associations

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