Interstitial cells of Cajal
Interstitial cells of Cajal (ICC) are myenteric cells which integrate between the enteric nervous system and the muscle components of the bowel. They are regarded as the pacemakers of the gastrointestinal tract.
Dysfunction of Cajal cells is implicated in dysmotility disorders.
They are best characterised with the gastrointestinal tract, but cells with similar morphology and molecular profiles have also been identified in the urinary tract and genital tracts, e.g. vas deferens, Fallopian tubes and vagina.
- ↑ Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology. 1996 Aug; 111(2):492-515.
- ↑ Metzger R, Schuster T, Till H, Stehr M, Franke FE, Dietz HG. Cajal-like cells in the human upper urinary tract. The Journal of urology. 2004 Aug; 172(2):769-72.(Link to article – subscription may be required.)
- ↑ Shafik A, El-Sibai O, Shafik AA, Shafik I. Identification of interstitial cells of Cajal in human urinary bladder: concept of vesical pacemaker. Urology. 2004 Oct; 64(4):809-13.(Link to article – subscription may be required.)
- ↑ Metzger R, Rolle U, Fiegel HC, Franke FE, Muenstedt K, Till H. C-kit receptor in the human vas deferens: distinction of mast cells, interstitial cells and interepithelial cells. Reproduction (Cambridge, England). 2008 Mar; 135(3):377-84.(Link to article – subscription may be required.)
- ↑ Popescu LM, Ciontea SM, Cretoiu D, Hinescu ME, Radu E, Ionescu N, Ceausu M, Gherghiceanu M, Braga RI, Vasilescu F, Zagrean L, Ardeleanu C. Novel type of interstitial cell (Cajal-like) in human fallopian tube. Journal of cellular and molecular medicine. 2005 Apr-Jun; 9(2):479-523.
- ↑ Shafik A, El-Sibai O, Shafik I, Shafik AA. Immunohistochemical identification of the pacemaker cajal cells in the normal human vagina. Archives of gynecology and obstetrics. 2005 Jun; 272(1):13-6.(Link to article – subscription may be required.)