Ivermectin

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Contents

Introduction

A macrocyclic lactone that interferes with γ-aminobutyric acid neurotransmission in invertebrates. There is wide clinical experience in moderate dose in onchocerciasis but it has evidence as an effective agent at various dose regimes in a wide range of parasitic invertebrate infections.

The drug was derived from one of the multiple avermectins first isolated from the soil bacteria (Streptomyces avermitilis) obtained from a Japanese golf course. William C Campbell and Satoshi Omura were recipients of the 2015 Nobel prize for this work.

Clinical Use

Indications

Administration

Oral

Clinical Issues

Resistence to the drug might develop[1][4]

Contra-indications

Cautions and Interactions

Side effects

Special advice

Pharmacology

Ivermectin is a nonselective inhibitor of mammalian P-type ATPases at high concentrations which raises the possibility of digitalis type effects which may be important as newer indications tend to use higher doses[5].

References