Axicabtagene ciloleucel

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rINN: Axicabtagene ciloleucel
Other Names
KTE-C19, axi-cel ®
Pharmacological Information
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Please read pharmacological data limitations
Other Wikis
Wikipedia on Axicabtagene ciloleucel (Less technical, ? quality control)
Axicabtagene ciloleucel is chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) preparation of autologous T cells genetically modified to express a chimeric antigen receptor (CAR) targeting CD19. The product is in development to treat adult patients with non-Hodgkin lymphoma (NHL), diffuse large B cell lymphoma (DLBCL)[1], primary mediastinal B-cell lymphoma (PMBCL), transformed follicular lymphoma (TFL)[2], chronic lymphocytic leukaemia and acute lymphoblastic leukaemia (ALL)[3]. It is a member of the EMEA's PRIority MEdicines (PRIME) scheme for breakthrough therapies. Licensing commenced in major markets 2017/18.

References

  1. ↑ Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Timmerman JM, Stiff PJ, Friedberg JW, Flinn IW, Goy A, Hill BT, Smith MR, Deol A, Farooq U, McSweeney P, Munoz J, Avivi I, Castro JE, Westin JR, Chavez JC, Ghobadi A, Komanduri KV, Levy R, Jacobsen ED, Witzig TE, Reagan P, Bot A, Rossi J, Navale L, Jiang Y, Aycock J, Elias M, Chang D, Wiezorek J, Go WY. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma. The New England journal of medicine. 2017 Dec; 377(26):2531-2544.(Print-Electronic) (Link to article – subscription may be required.)
  2. ↑ Kite Pharma, Inc Press release 28 Feb 2017
  3. ↑ Press release Kite Pharma 8 August 2017
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