Lacosamide

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Contents

Introduction

Developed to treat partial-onset epilepsy and painful diabetic neuropathy. Does not seem to work in this second postulated indication for more than a few months[1]. May be freer of drug interactions than many other anticonvulsants and can be given easily iv[2] as well as orally.

Clinical Use

Indications

As a second anti-epileptic drug and as above.

Administration

  • Oral in range 400 to 600mg tital dose daily
  • iv seems to be well tolerated

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

Special advice

Pharmacology

  • Elimination half-life about 13 hours
  • linear, dose-proportional pharmacokinetics with low intrapatient and interpatient variability

References

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