Lactate dehydrogenase

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Polypeptide enzyme that classically catalyses (S)-lactate + NAD+ <=> pyruvate + NADH.

In man :

The gene LDHA (PIG19) codes for L-lactate dehydrogenase A chain (LDH muscle subunit, renal carcinoma antigen NY-REN-59, cell proliferation-inducing gene 19 protein, LDH-M LDH-A, EC:

The gene LDHB codes for L-lactate dehydrogenase B chain (LDH heart subunit, renal carcinoma antigen NY-REN-46, LDH-H, LDH-B, EC:

  • Defects cause of hereditary LDHB deficiency which is usually asymptomatic

The gene LDHC codes for L-lactate dehydrogenase C chain (LDH testis subunit, cancer/testis antigen 32, EC:, LDH-C, LDH-X, CT32)

  • Expressed in sperm

The gene LDHD codes for a 507 amino acid peptide believed to be mitochondrial D-lactate dehydrogenase (Lactate dehydrogenase D, DLD, EC:

  • Two isoforms
  • Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.
  • Catalyses (R)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c.

The gene LDHAL6A(LDHL2) codes for a testis-specific 332 amino acid peptide with lactate dehydrogenase A-like properties

The gene LDHAL6B (LDHAL6, LDHL) codes for a adult testis-specific 381 amino acid peptide with lactate dehydrogenase A-like properties