Lactose intolerance

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Lactose intolerance (primary hypolactasia) is predominantly associated in adult caucasians with a single nucleotide polymorphism in intron 13 of the MCM6 gene upstream of the chromosome 2 LCT gene for lactase. It has been postulated the Charles Darwin had this problem[1]. Actually primary hypolactasia rates vary between about 8% in Northern Europeans to 100% in Thais reflecting the strong selective pressures of European farming practices on their population.


Some parents believe that common infant behaviours such as fussiness, crying, or need for attention are caused by lactose intolerance. This is not supported by evidence.[2]

However the rare congenital lactase deficiency in infants is a serious condition leading to failure to thrive due to the predictable severe diarrhoea, even when breast-fed.


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