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The LMNB2 gene at 19p13.3 codes for the 600 amino acid pro-peptide of lamin-B2 a lamin B component of the nuclear lamina.

Mutations of LMNB2 are a cause of partial acquired lipodystrophy (APLD) characterized by childhood loss of subcutaneous fat from the face and trunk. Many of the mainly females affected develop glomerulonephritis, diabetes mellitus, hyperlipidaemia, and/or complement deficiency. Mental retardation has been reported.

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