Lansoprazole

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Contents

Introduction

Lansoprazole is a proton pump inhibitor with a fair evidence base but not as extensive as omeprazole.

Clinical Use

Indications

Administration

Oral

IV

Clinical Issues

Group Clinical Issues

Toxicity

Group Contra-indications

Group Cautions and Interactions

  • There is now epidemiological evidence from two studies that all inhibit the actions of clopidogrel[1] when previously it was hoped the interaction was more specific. However clinically this interaction appears to be only significant for omeprazole and possibly esomeprazole.
  • There is to date an unexplained association between use in the frail institutional elderly and mortality. As absolute annual mortality increased from 26.6% to 33.3% this may be due to confounding.

Group Side effects

Special advice

Don't measure gastrin levels if a patient is on a PPI (or at least do not panic when you get the result back !).

Pharmacology

References

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