Latency-associated peptide

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Latency-associated peptide can be regarded as the membrane bound isoform of transforming growth factor beta-1 when not cleaved from transforming growth factor beta-1.

Transforming growth factor beta-1 (TGF-beta-1) is cleaved from latency-associated peptide (LAP). It is from a 390 amino acid pro-peptide coded by the TGFB1 gene at 19q13.1. Amino acids 30 to 278 make up latency-associated peptide and amino acids 279 to 390 transforming growth factor beta-1.

  • Controls proliferation, differentiation, and other functions in many cell types including of note osteoblasts.
  • Defect associated with Camurati-Engelmann disease (CED, progressive diaphyseal dysplasia 1).
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