Lennox-Gastaut syndrome

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Lennox-Gastaut syndrome is a form of childhood onset severe epilepsy.

It is characterised by:

  • Seizures usually before 4 years that are
    • Very frequent-25 a day or more
    • Refractory to treatment
    • Wide variety of types
  • Impaired intellectual functioning, information processing and/or behaviour.
  • Developmental delay
  • EEG shows diffuse slow spike waves (<3Hz) and bursts of fast (10Hz) waves during sleep. (first correlated in 1950 by William Gordon Lennox)

There are multiple causes (which may influence the usually poor prognosis):

  • Idiopathic
  • Brain malformations
  • Brain damage
  • Congenital and childhood central nervous system infection
  • Genetic conditions.


  • About 1 in 10,000 (5% of all childhood epilepsy)

see also

NIH general information